Sentence examples for more profound defect from inspiring English sources

However, the fact that sister chromatids were not very motile when Ark1 is inhibited could also indicate a more profound defect in kinetochore microtubule dynamics.

Studies by Wagner and colleagues [ 4] and by Koetz and colleagues [ 26] examined whether the clonal expansions were indicators of a more profound defect in T-cell homeostasis (Fig. 1).

In a side-by-side comparison, rev1 cells exhibited a more profound defect in fork progression following damage than wrn cells (Fig. 4B), but importantly the double wrn/rev1 mutant was no worse than rev1 on its own.

CONCLUSIONS Compared with youth with NGT, obese adolescents with IGT have evidence of a β-cell defect manifested in impaired first-phase insulin secretion, with a more profound defect in type 2 diabetes involving both first- and second-phase insulin.

In beclin 1+/− mice also lysosomal abnormalities are noted, while their crossing with an APP-based AD mouse model results in higher intraneuronal and extraneuronal Aβ levels, more profound ultrastructural defects, including more severe lysosomal/autophagic abnormalities as well as increased neurodegeneration [ 107].

The nth-1 xpa-1 double mutanth-1 xpa-1re profoundoublerepair defect and is expected to be unable to repair a mutantider spectrum of DNA lesions.

These defects were significantly more profound in cells deficient for both ezrin and moesin [12], indicating that there is significant functional redundancy between ezrin and moesin in mature T cells.

Notably, the muscle pathology in congenital DM1 more closely resembles a developmental or congenital myopathy (as opposed to a dystrophy) and the cognitive defects are much more profound.

In HSCT, more intense chemotherapy is applied than in induction or consolidation chemotherapy, and total body irradiation is also given, so the duration of neutropenia is much longer and the defect in immunity is more profound.

Although this might account for their poor performance in this test, the overall defect in muscular strength is more profound and involved more than an inability to grip.

More profound alterations and a higher incidence of structural defects in HLA Class I expression were found in post-BCG-recurrent tumors.