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The proHGF treatment produced a more profound decrease in pluripotent genes and increase of differentiation genes than did the other experimental treatments (Figs. 2C, 2D, and S4).
By contrast, there was a more profound decrease in PvO2 and saturation in the saline hemodiluted group (Tables 1 and 2, Fig. 1, p < 0.05).
A recent study demonstrates that wild-type magA+ and trans-complemented magA organisms grow more rapidly and cause a more profound decrease in ERG a- and b-waves and cellular infiltration in a mouse model than the magA deficient organism [29].
For instance, forcing fatty acid synthesis with citrate produced a greater increase in the formation of SFA in SCD1-deficient when compared to normal cells and a more profound decrease in cell proliferation.
Nevertheless, continuous parenteral delivery of the tyrphostin JAK2 inhibitor AG-490 to polycythemic mice caused a modest but significant drop in hematocrit, with a more profound decrease in reticulocyte count.
PCNA staining of PTEN +/+ and PTEN −/− gliomas (Fig. 4A,B) demonstrated a slight qualitative decrease in proliferation for perifosine treated animals with a more profound decrease seen in CCI-779 and in the combination treatment groups.
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The lack of efficacy may be related to the number of ablations, since in a subset of patients of Symplicity HTN-3 a more profound BP decrease was observed in patients with more ablations, suggesting a relation between the quantity of ablations and the BP lowering effects [4].
This decrease was more profound than the decrease in overall brain weight (33% for males and 35% for females; Fig. 2B) or body weight (16% for males and 23% for females; Fig. 2C), indicating that the cerebellum is especially sensitive to a decrease in the level of MDM2.
In the present study, walking with higher speed increases HDL-c more, but at the expense of less LDL-c decrease, and walking with lower speed leads to less HDL-c increase but a more profound LDL-c decrease.
In two randomized controlled studies and 2 recent meta-analyses, rasburicase administration was associated with a more rapid and profound decrease in uricaemia as compared with allopurinol [209 211].
This is in contrast to the results based upon the more profound criteria of a decrease to an absolute value of <1%.
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