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A reason for the more problematic prediction of these bonds may reside in their frequent involvement in hydrogen bonding – determined by 3D through-space interactions not currently encoded by our descriptors.
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In contrast, the pair potential method requires generating 3d models of peptide:MHC molecules for each possible register, which takes minutes per peptide, and makes genomic scale predictions more problematic.
Prediction across breeds is more problematic because different breeds may exhibit different QTL, dominance or epistasis can occur, and allele frequencies may vary between populations.
The Kalman filter and other methods may be formulated such that poor quality decoders can be isolated and removed from the prediction without retraining, while the ANNs would be significantly more problematic.
In contrast, pursuit of biomarkers that reflect chemosensitivity of cytotoxic agents had been more problematic, and the in vitro chemosensitivity test remains a practical option in prediction of response to chemotherapy.
It is clear that prediction for all traits under both marker densities is always more problematic under SS than under WW conditions.
"This is more problematic".
That is more problematic.
College years are more problematic.
More problematic is Alice herself.
Private equity is more problematic.
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