In definitive radiotherapy for prostate cancer, late adverse effects tend to be more problematic than acute adverse effects.
Direct comparison of gene expression values from multiple studies may be relatively more problematic than comparing the effect size obtained from individual studies.
It becomes more problematic when a DIF effect is found for an established HRQoL questionnaire: researchers need to consider carefully how this will affect future studies.
Individual effects are more problematic.
It is potentially more problematic that studies on treatment effects generally have been performed in Caucasian populations, and the transferability to black African populations is uncertain.
Now we know that the atypicals are no more effective than the older drugs, and are perhaps even more problematic, in terms of their side effects.
More problematic was the visible-bra effect from Mr. Saunders.
The abstract of the paper describes this as a "weaker effect", but more problematic is that the paper dates back to 2004 – before Facebook and Twitter even existed, online demographics were rather different to today, and a lot of students were still pretty new to the internet.
These physical problems are typical for breast cancer treatment and have long-lasting effects; becoming even more problematic with increase in age.
These effects are clearly more problematic in patients with Cushing's disease or women with underlying diabetes than they would be in otherwise normal individuals.
