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In this study, we utilized the stemness gene Oct4 to directly induce reprogramming of adipose tissue stromal cells (ATSC) into more primitive stem cells overexpressing stemness genes including Oct4, Sox2, and Nanog.
Additionally, MSCs do not form tumors as other more primitive stem cells such as embryonic stem cells.
The amniotic fluid and the placenta are unique sources of different populations of stem cells mesenchymal, hematopoietic, trophoblastic and, possibly, of more primitive stem cells.
Since the 20 neurons we analyzed were all from cultured human neurons differentiated in vitro from more primitive stem cells, we wonder whether the neuronal maturation genes (138) we identified could be used generally to mark neuronal maturity.
The results of these studies indicate that ATSCs possess their own multipotency to reprogram into more primitive stem cells, with the exception of chromosomal abnormalities and point mutations (data not showed).
Our data suggest, confirming the findings of Dellavalle et al, that CD56− cells may represent a more primitive stem cell that can give rise to more differentiated CD56+ cells during in vitro culture (Figure 3).
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In this restricted taxonomy, Kenyapithecus is somewhat younger and differs not only from the more primitive STEMs but specifically in ways that link it to more modern fossil and living apes (Fig. 3).
Thus, under standard in vitro growth conditions, dedifferentiation of NSCCs to a more primitive, stem-like state and differentiation of CSCs to NSCCs occurs at the same time.
These cells, which resemble normal stem cells and are hierarchically more primitive, express stem cell-related marker genes and are highly resistant to standard chemotherapeutic agents as well as radiation [ 9, 10].
However, ER- stem cells resident in the mammary tissue have also been identified and might represent the more primitive mammary stem cells.
Fetal liver provides a richer source of more primitive hematopoietic stem and progenitor cells than does fetal blood.
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