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On opposition, stem cells of these tissues, such as hematopoietic stem cells (HSC) of the more primitive phenotype, are proficient in DSB repair [53].
We further examined whether transdifferentiation of AL cells into HL cells happens directly or through the process of dedifferentiation, into a more primitive phenotype.
By contrast, LRCs isolated at later stages of muscle maturation (P21 onwards) maintain a more primitive phenotype during proliferation, as compared with nonLRCs (Fig. 3B).
To this end, adipocyte-like cells (AL cells) derived from AF-MSCs can regain, under certain culture conditions, a more primitive phenotype through the process of dedifferentiation.
DAF-MSCs showed higher expression levels for Oct-4, Sox-2 and Nanog compared with AL cells, documenting a more primitive phenotype of these cells.
In conclusion, similar to postnatal muscle, LRCs isolated from regenerated adult muscle maintain a more primitive phenotype during proliferation in vitro.
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Johnston et al. have further suggested that cellular progression to a cancerous phenotype may represent a reversion of metazoan cells to a more primitive evolutionary phenotype whose "freedom to proliferate" occurs at the expense of the host's long-term survival [ 5].
In the absence of this chemical cocktail the cells retain a more primitive fibroblastic phenotype.
A spindly genealogical tree is indicative of population turnover, wherein novel antigenic phenotypes continually replace more primitive 'spent' phenotypes, purging their genealogical diversity.
These results support the notion that serum of neutropenic patients enhances proliferation of HPC and maintains their primitive phenotype for more cell divisions.
In addition, these molecules may identify a subset of tumors with a more primitive and possibly a more aggressive phenotype.
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