A variety of cell types can be identified in the adherent fraction of bone marrow mononuclear cells including more primitive and embryonic-like stem cells, mesenchymal stem cells (MSC), lineage-committed progenitors as well as mature cells such as osteoblasts and fibroblasts.
Indeed, besides MSC a variety of different cell types of predominantly mesodermal origin could be identified in the adherent fraction of bone marrow mononuclear cells including more primitive and embryonic-like stem cells, lineage-committed progenitors as well as mature cells such as osteoblasts and fibroblasts [ 13- 16].
They are neoplasms deriving from more than one primitive embryonic layer (ectoderm, mesoderm, endoderm), represent approximately one third of all neonatal tumors and typically arise in the sacrococcygeal region or the gonads [ 8– 10].
Additionally, MSCs do not form tumors as other more primitive stem cells such as embryonic stem cells.
Embryonic stem cells, more primitive stem cells, are likely to be potentially immortal and capable of indefinite self-renewal together with the ability to differentiate and contribute to the germ line.
Although development doesn't necessarily replay evolutionary history, says paleontologist Eric Buffetaut of the basic research agency CNRS in Paris, embryonic features may be reminiscent of more primitive sauropods.
In addition, it has been found that MSCs derived from human umbilical cord Wharton's jelly, which express certain embryonic stem cell (ESCs) markers (such as NANOG, DNMT3B, and GABRB3), are more primitive than those isolated from other tissue sources [ 13].
Less schooled; more primitive.
"The more primitive the better for me.
It's more primitive, in a sense, like keypunches.
