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These results indicate that when FD cells are turned back into a more "primitive" developmental stage, IKBKAP aberrant splicing is corrected, as was described during the fibroblast to iPS cell reprogramming process [22].
The endothelial marker expression at an early phase of mesoderm differentiation might reflect the default endothelial commitment of extraembryonic mesoderm [ 76], being a transient "leftover" from a more primitive developmental program [ 77], or it manifests yet unknown regulatory function of some endothelial markers in the hematopoietic development [ 78].
Our transcriptomic evaluation also revealed that expression levels of progenitor markers such as CD133, CD34, and C-Kit were higher in CB-derived OECs than in their PB counterparts indicating an apparent cell immaturity which is consistent with their more primitive developmental stage and higher proliferative capacity [ 24].
Similar(57)
Less schooled; more primitive.
"The more primitive the better for me.
It's more primitive, in a sense, like keypunches.
Indeed, it is more primitive than the original.
So why buy a more primitive e-book reader?
The more primitive species have perennial, green shoots.
The Mahars' first efforts to protect Katie were more primitive.
Another, more primitive part of us makes no such discriminations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com