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The presence of GEMM colonies, in comparison to the control, signifies the preservation of more primitive cells in those sets.
Therefore, in analogy with the hematopoietic system, we initially hypothesized that within the satellite cell compartment the minority of CD34− cells may represent more primitive cells upstream of the more abundant CD34+ population.
The signature associated with these more primitive cells may be more representative of the majority of human AML samples.
As expected, nilotinib induced only a moderate apoptosis (P=0.005) on CD34+/CD38−that are more primitive cells and this effect was not inhibited by SCF.
Instead of osteoblasts, we chose porcine bone marrow mesenchymal stem cells (PBMSCs) as cell sources because they are more primitive cells with better capacity of proliferation and differentiation.
Our original observation of an increased number of K6a-positive cells in the mature mammary glands from C/EBPβ-null mice correlated with a block in development, suggesting an accumulation of more primitive cells [ 6].
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Once inside, the plasmids trigger the cells to revert to a more primitive cell state that can be coaxed into various cell types.
Basic research in these and other areas are turning attention to more and more primitive cell lines in order to craft effective, nontoxic treatments.
In contrast, WJ-MSCs express cell surface markers CD29, CD44, CD73, CD90, CD105, CD146, and CD166 [69] 69] and are considered more primitive cell population relative to BM-derived MSCs [70].
The combinatorial action of B/M upon HL60 differentiation was confirmed by the reciprocal loss of the more primitive cell marker CD71 (Figure 2B).
Compared with MSCs, these cells were thought to be a more primitive cell population with partially overlapping ontogeny.
More suggestions(15)
more positive cells
more primitive weapons
more primitive ones
more red cells
more specialized cells
more differentiated cells
more microbial cells
more primitive technologies
more primitive goods
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more primitive salamanders
more militant cells
more fat cells
more primitive species
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