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Exact(8)
Panobinostat (a pan histone deacetylase inhibitor) is approved in combination with bortezomib and dexamethasone for patients with relapsed multiple myeloma who have received two or more previous lines of therapy.
Owing to the slow but sustained progress made in lung cancer treatment over the last 20 years, several therapeutic options are now available in the first-line setting as well as for patients who have progressed after one or more previous lines of treatment.
Forty-four per cent of patients in arm A and 45% of patients in Arm B received two or more previous lines of chemotherapy.
The majority of patients had received two or more previous lines of chemotherapy, although 20.7% had only received one previous chemotherapy regimen.
The population in the current study was heavily pretreated, having advanced-stage disease; the majority of patients had received three or more previous lines of treatment and ∼40% of patients had prior EGFR inhibitor therapy.
In this sudy, 83% of patients had received two or more previous lines of chemotherapy, and only one patient was treated with cetuximab as first-line therapy for mCRC.
Similar(52)
Heavy prior therapy may prejudice successful harvesting, and treatment with purine analogues and three or more previous chemotherapy lines are predictive factors for poor mobilisation; these all lead to a high score in both our scoring systems.
Eligibility criteria were as follows: histological diagnosis of prostate adenocarcinoma, castration-resistant disease, inability to receive standard chemotherapy because of toxicity concerns or failure of one or more previous chemotherapeutic lines of treatment for metastatic disease.
Each of the following conditions represented an exclusion criterion: more than two previous lines of chemotherapy; incomplete recovery from surgery or radiation therapy; previous chemotherapy within 4 weeks of study entry; uncontrolled infections; significant cardiac impairment; and history of sensitivity to sulphonamides or platinum agents.
Patients were enrolled onto this study if they met the following criteria: histologically confirmed advanced cancer, for which other forms of therapy had failed or were considered inappropriate; no more than one previous line of chemotherapy, >4 weeks prior to enrollment; no prior exposure to a taxane or ifosfamide.
Draw more slanted lines connected to your previous lines.
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more previous attempts
more previous STDs
more previous admissions
more previous frames
more previous convictions
more previous failures
more connecting lines
more wavy lines
more previous episodes
more previous pregnancies
more previous OIs
more previous fractures
more red lines
more previous abortions
more straight lines
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com