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Ever use of each diabetes medication (defined as two or more prescriptions within 6 months) was treated as a time-dependent variable.
For oral corticosteroids, four or more prescriptions within the 12-month period were considered to indicate regular use rather than acute use for COPD exacerbation(s).
Recent users were those who had three or more prescriptions within two years of index date (that is, between one and two years before index date).
We reported the number of individuals with one or more prescriptions within a year for each of the following medications: antipsychotic drugs (first, second generation and depot injections), tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs) and other antidepressants.
Each individual was classified for exposure to AP as current user (one or more prescriptions within three months before index date); recent user (one or more prescriptions in the period between 4 and 12 months before index date); past user (one or more prescriptions 13 months or more before index date).
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As such, a definition for "long-term user", which includes individuals with longer exposure to APs, was defined as individuals with two or more prescriptions for APs within 180 days and the cumulative days supply from these prescriptions was required to be a minimum of 90 days.
Exposed cohort: All women ≥18 years undergoing a primary surgical procedure for UI between 1 January 1996 and 31 December 2010 in the county of Funen/Region of Southern Denmark, and having redeemed one or more prescriptions on antibiotics within 365 days preceding the date of surgery (index date).
Conversely, of individuals filling two or more prescriptions for aspirin within 1 year prior to enrolment, 98% reported its use in the questionnaire at enrolment; the corresponding figures for non-aspirin NSAIDs were 78 and 96%, indicating some misclassification of self-reported data.
Patients who filled only a single pioglitazone prescription (n = 4,679) or who filled two or more prescriptions that were never within 6 months of each other (n = 580) were not categorized as exposed according to our definition.
Furthermore, responders had received more prescriptions of different drugs within one year (mean total number of different drug prescriptions: 8.3 ± 4.8 vs. 7.5 ± 5.2; p ≤ 0.001), which can be interpreted as a gross indicator of greater morbidity.
They fill more prescriptions and make more doctors' visits.
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