Others, like Tyler Hamilton, who was diagnosed with clinical depression in 2003, may show a more classic predisposition with a well-established family history – his grandmother committed suicide when his mother was 13.
"Although commonly assumed to be a modern disease, the presence of atherosclerosis in pre-modern human beings raises the possibility of a more basic predisposition to the disease," according to the researchers, who include specialists in cardiology, X-rays, anthropology and other fields.
Our laboratory tests the hypothesis that life-threatening diseases of childhood, typically in the course of primary infection, each result from a collection of highly diverse but immunologically related single-gene variations; whereas the corresponding infections in adults, typically caused by secondary infection or reactivation of latent infection, reflect a more complex predisposition.
This finding suggest that the skew is not specific for the antigen (i.e. MBP) that is driving MS, per se, but is a more general predisposition of these patients T cells.
One area of possibly more fundamental predisposition to atopy is that of nutrition and diet.
Several mechanisms have been postulated to explain the association, some of which might be particular to MS, but others would be expected to cause a more generic predisposition to autoimmunity.
As childhood TB seems to have more genetic predisposition [ 5], we thus tried to discuss the associations of IL-6 and IL-6R with Chinese pediatric TB by single polymorphism genotyping (SNP) based case-control study.
NF1 (neurofibromin) is a tumour suppressor that antagonises Ras, and loss-of-function mutations of NF1 are associated with the familial neurofibromatosis type 1 tumour syndrome (Recklinghausen disease), which is characterised by development of benign tumours of the nervous system, as well as a more general predisposition to cancer (Ref. 61).
"Values" are said to represent very broad tendencies of this type, "interests" being slightly less inclusive, and "sentiments" narrower still; "attitudes" are viewed as still more narrow predispositions, with "beliefs" and "opinions" being progressively the most specific members of this hierarchy.
Plugged The roof that costs too much Beware the K-Street conservatives Reprints Related items Erring priests: A policy of sortsJun 6th 2002 A priestly scandal in Boston: Better admit itJan 31st 2002For Cardinal Law, bankruptcy would mean no more legal predispositions where he has to answer awkward questions.
