On the other hand, the fully differentiated cell therapy product may represent a "safer" product since it is a post-mitotic cell population (i.e., low risk of tumor formation) which can be more precisely dosed.
Either way, the calculations given here correspond at best to only rough approximations since we did not attempt to define more precisely the dose-dependence relationship for BSF insofar as mineral precipitation is concerned.
The present report summarises the toxicity and pharmacokinetic profile (Pk) of BM with the latter schedule when used in patients with solid tumours with the aim to define maximum tolerated dose (MTD), dose-limiting toxicity (DLT) and to recommend more precisely a safe dose for future phase II studies with this schedule.
The main advantage of this therapy is the ability to localize the radiation dose more precisely and control where the proton releases the bulk of its cancer-fighting energy, although the exact dose generated from neutrons is still a concern [ 51].
In an attempt to characterize PCE exposure more precisely, we constructed a dose model that considered exposure from inhalation, ingestion, and dermal absorption.
By taking part in the MIRANDA study patients are offered the possibility to determine the applied dose more precisely, since by using the PET/CT for monitoring the activation produced by the particle beam can be visualized.
It was expected that parenteral treatment was dosed more precisely than oral treatment.
54 Proton beam therapy is expected to deliver biologically equivalent doses more precisely and with less radiation-induced morbidity than conventional photon radiation therapy.
Further analysis of these data and pursuit of additional sources to improve the characterization of the benzene exposure of this cohort appear to be warranted in order to define more precisely the benzene-leukemia dose-response relationship.
That way you can titrate the dose down more precisely and rapidly.
IMRT allows for the radiation dose to conform more precisely to the three-dimensional shape of the tumor by modulating or controlling the intensity of the radiation beam by computerized treatment planning system calculation and dose delivery through Multileaf Collimator.
