"Ultimately, the finding could lead to more precise therapies for preterm babies," says neonatalogist Samuel Hawgood of the University of California, San Francisco.
"This is a tangible result of the nation's increased investment in medical research over the past ten years... We stand on the threshold of creating a future that will revolutionize the practice of medicine by allowing us to predict disease, develop more precise therapies and, ultimately, preempt the development of disease in the first place".
Drug-induced gene expression signatures identified in panels of cancer cell lines can potentially enhance such approaches to elicit more precise and personalized therapies that would lead to better clinical outcomes.
We anticipated that this study could provide novel insight and more precise guidance for cell therapy based on MSCs, e.g. to introduce MSCs sufficiently close to the disease foci.
Therefore, a more accurate definition of tumor boundaries would facilitate more precise delivery of radiation therapy and as a result decrease normal tissue exposure to undesirable radiation.
While many current drugs provide effective therapies, more precise delivery to target sites can increase net potency and reduce toxicity.
"We will have [a] more precise prediction of efficacy of therapy and possible side effects before we do clinical trials," Anand told The Huffington Post via email, explaining how his model is a more ethical alternative to trials that use rodent specimens.
Based on the patients' clinical outcomes, we found that only the 30% threshold could give more precise instruction for anti-HER2 therapy.
This issue will become increasingly pressing as genome sequencing technologies become more accessible and as our ability to manipulate immune modulation improves, requiring more precise selection of the right therapy for the right patient.
Comprehensive evaluation of on-target and off-target effects of sgRNA will allow more precise genome editing and gene therapies using the CRISPR system.
