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A more precise staging system for early-stage disease patients is required.
Moreover, developmental landmarks, including hatching, larval molting, mounting, spinning, pupariation and eclosion, were employed for more precise staging.
Therefore, it is extremely important to reach an accurate diagnosis, which can facilitate more precise staging and prognostic estimations, as well as evaluation of response to therapy.
Because fish developmental growth rates strongly depend on breeding conditions (e.g., temperature, density, food quality) and therefore could vary among research facilities, we chose to use a more precise staging system proposed by other authors (Parichy et al., 2009; Sire et al., 1997) using larvae length as an index of development instead of dpf.
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Some of the earlier studies that reported significant full-field ERG changes in diabetes patients had included the additional performance of fluorescein angiography [ 16– 18], which may have the advantage of more precise retinopathy staging.
For instance, the discovery of signature genes for breast cancers through microarray analysis of gene expression has provided us with a more precise clinical staging that will improve the outcome of treatment [ 20, 21].
Without specific stage and viability markers, it is impossible to attribute a more precise developmental stage and viability condition to individually selected IRBCs under confocal observation.
Grape berry development consists of two successive sigmoidal growth periods separated by a lag phase; from anthesis to ripening it can be divided into three major phases [ 3] with more detailed descriptive designations, known as the modified E-L system, being used to define more precise growth stages over the entire grapevine lifecycle [ 4].
8 9 However, more precise information on staging and typing is required for clinical decision-making.
A richer data set, with full data on treatment and co-morbidity, might have enabled more precise imputations of stage, because the main assumption behind imputation is that stage can be predicted from other variables in the data set.
These codes combined population and commuting data to provide more precise definitions of stages along the urban-rural continuum [ 9].
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