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Establishment of more precise prognostic determinants using molecular biology techniques is warranted to make the best use of these options.
Lymph node ratio category has advantages in providing a more precise prognostic value than the pN category 5th edition, UICC).
As an alternative, more precise prognostic calculators have been developed for GBM patients receiving RT/TMZ [ 14, 29].
Therefore, it is critical to discover more precise prognostic marker and real-time methods for HER2 testing to optimize individualized therapeutic regimens for HER2-positive MBC patients.
A large, multicenter study including Western countries may provide more precise prognostic values and may help determine the utility of aEEG in this population.
A major challenge we face with the TNM staging system is how to modify the M categorization system for a more precise prognostic prediction and treatment planning.
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Also, the present diversity of computer architectures cannot fit in one model; the experimentation on current computers is relevant and necessary to gain more precise prognostics about EA performance and robustness.
This improves the likelihood that genuine metabolic biomarkers for breast cancer tissues can be detected and validated, and will eventually lead to diagnostic toolkits that will facilitate a much more precise predictive and prognostic assessment.
Therefore, it is extremely important to reach an accurate diagnosis, which can facilitate more precise staging and prognostic estimations, as well as evaluation of response to therapy.
We have therefore reviewed all the published studies that have investigated the association between somatic mutations in the p53 gene and breast cancer prognosis and used standard techniques of meta-analysis to combine the results of these studies to produce a more precise estimate of the prognostic significance of p53 mutations.
Even if genetic screening could have been more precise, our observation of a negative prognostic role of BM GD2-IC positivity suggests that also this technique, which has become accurate, thanks to recent standardisation (Swerts et al, 2005), might be of interest in future studies.
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