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This model slightly improved the fit and gave more precise parameters.
The current need for long-term follow-up can be hopefully avoided by the introduction of more precise parameters to estimate disease severity beyond the dependence on mechanical ventilation and oxygen supplementation at 36 weeks of gestation.
Drugs with varying patterns of use and drugs used on a short-term basis only require more precise parameters.
BDS guidelines recommend the use of a computer-based evaluation of glycemia data to generate more precise parameters such as glycemic profiles, average glycemia, and glycemic variability.
In the same manner, more precise parameters derived from pressure-volume analysis being insensitive to preload effects confirmed significantly improved systolic function after levosimendan treatment when compared with epinephrine.
Drugs that tend to have a varying pattern of use (i.e., multiple indications with different dosage ranges, for example antipsychotics), and for drugs that are only used on a short-term basis (such as antibiotics), or with seasonal variation patterns that require more precise parameters.
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Additional experiments, based on a D-optimum design of experiments, were performed to obtain more precise parameter estimates as required for final model discrimination.
In this study we have taken the approach to fit many parameters and then try to use more efficient experimental designs to break the correlation structure and thus obtain more precise parameter estimation despite the large number of fitted parameters.
The bivariate ZINB (BZINB) models have been found to have desirable distributional property to describe the relationship between the large truck involved crashes and geometric design features in terms of better goodness of fit, more precise parameter estimates, more identified significant factors, and improved predictive accuracy.
As a result, it provided more precise parameter estimates and increased statistical power.
Syvänen et al. [26] analyzed data from a (R -11C]verapamil PET study in naïve and post SE R -11C]verapamil after kainate treatment) with both a PET PK-modeling approach and a NLME-modeling approach and concluded that both approachestudyduced sinilar PK parameter estimates, but that naïvemodeling provided more precise pandmeter estimates.
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more precise assessments
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more restrictive parameters
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