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As noted above, survival has the advantage of being a more precise endpoint than response, but it has the distinct disadvantages of being impacted by a variety of factors unrelated to therapy efficacy, one cannot tell which patients actually benefited from therapy, and it requires several months or years of patient follow-up time.
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Measures may also be repeated in order obtain a more precise estimate of an endpoint.
For HBeAg-negative CHB patients, relapse is frequent even when HBV DNA levels have been suppressed to undetectable for more than one year, making the precise endpoint for NUCs withdrawal unclear.
Strong acid titrants give more precise results due to a more distinct endpoint.
In this larger population, which should provide a more precise risk estimate, the relative risk (95% CI) for a composite endpoint of adjudicated CV death, MI, and stroke was 0.75 (0.46, 1.21), suggesting no increased risk of MACE in this 20-study pool.
Our regression schema, an online resource we have created for all investigators, and the tabulated form will be used to enhance uniformity of evaluation and provide quantitative endpoints which we can use to provide a more precise, consistent means of evaluating assessment at the end of the study.
To minimise the differences in survival calculations between studies and to enable more precise comparisons of studies we recommend the general use of the definition of endpoints published in the consensus document of Punt et al [ 4].
Much more precise.
Let me be more precise.
Bush has been more precise.
Her cuts are more precise.
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