The revised structure of the Bayley-III [ 8], which includes distinct composite scores (Cognitive, Language and Motor), allows a more precise assessment of specific developmental domains.
Putative HCNE peak targets are characterized by a tight association with particular promoter motifs, higher incidence of severe mutant phenotypes, and evidence of a more precise regulation of gene expression during important developmental transitions.
We hypothesized that more frequent sampling would reveal unappreciated patterns in gene expression, and provide a more precise understanding of the transcriptional dynamics that govern major developmental transitions.
By monitoring developmental trajectories in high-risk siblings more precise information about the first appearance of autistic behaviors has evolved (for reviews, see [ 20, 25, 27]).
Moreover, a developmental pattern was observed in which older infants are more precise in targeting their saccades than younger infants.
Many of these developmental genes have shadow enhancers, which are thought to make gene activity more precise and reliable.
Moreover, developmental landmarks, including hatching, larval molting, mounting, spinning, pupariation and eclosion, were employed for more precise staging.
This demands (i) a more precise view of genome organisation and composition, and gene structure, (ii) detailed expression profiles from multiple cell types, and developmental and physiological contexts, and (iii) the capacity to experimentally manipulate gene function.
