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In 10 (37%), a more precise annotation was obtained, and in five (18%), a significant reannotation was enabled.
This problem can be slightly alleviated for contigs as contigs are longer and the alignment can be more precise, thus resulting in a more precise annotation.
The 20 P. berghei predicted genes for which there are no obvious P. falciparum orthologues could correspond to incomplete genes and require more precise annotation.
Recent progress in sequencing and 3 D structure determination techniques stimulated development of approaches aimed at more precise annotation of proteins, that is, prediction of exact specificity to a ligand or, more broadly, to a binding partner of any kind.
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Thus, the more precise the annotation, the better ETA structural genomics networks perform relative to sequence comparisons.
A more thorough accumulation of full-length cDNA information is necessary for more precise genome annotation of Pf.
With the consensus logos, we may have more precise TF annotation but many chromatin-remodeling TFs are not included in consensus logos such as MAX and HDAC1.
UniProtKB/Swiss-Prot annotates exclusively proteins and has more precise protein annotations than dictyBase does.
We next provide finer and more precise functional annotations (i.e. improved GO depth) by curating literature.
To make further progress in this field a consensus based 'Hybrid' approach which includes the positive aspects of transcriptional signals and consensus secondary structures, together with thermodynamic stability analysis and ncRNA specific features, could give more precise sRNA annotations.
Since we are analyzing spatial patterns of genes that are differentially expressed in the embryonic stage, without any analysis across time, we expect to find enrichment of smaller, more precise functional annotations that are related to specific areas of embryonic development, and GO Slim is not appropriate.
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