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The image after segmentation has much cleaner signals for more precise alignment and further analysis.
This precision motivated our work of the past 8 years (Wriggers et al., 2000) to allow conformational flexibility for a more precise alignment with low-resolution features that deviate from the atomic model.
Considering the advantages of reduced phase noise and more precise alignment of the profile with respect to the lumen center, all blood velocity calculations were made using radial profiles.
The tremendous amount of tumor-derived genomic information available now, and after completion of several large-scale cancer sequencing efforts, combined with biological validation of mutations to determine relevant drivers, will allow for much more facile identification of new targets for drug discovery, as well as more precise alignment of patients with a particular targeted therapy.
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We note however, that this would require significant conceptual changes to Xenome since it requires relatively more precise alignments.
In 2007, Ashburner published a diffeomorphic registration algorithm (DARTEL) that improved the computational anatomy and functional MRI data analyses as they allowed for more precise intersubject alignments.
Alignment was done by eye (the world's haplotypes were already pre-aligned and it is faster and more precise to align by eye than using an alignment function).
While this is not perfectly fine-grained, it is much more precise to the alignment than is OKI's full-corridor methodology.
Paired-end read data generated by Illumina sequencing could allow more accurate alignment of raw reads compared to single reads from 454 RNA-seq, and thus the SNP calling process would also become more precise.
We believe that the use of externally verified alignment scores is a far less biased and more precise metric of aligner accuracy because it isolates the effects of alignment heuristics from the mapping quality heuristics.
This orientation is comparable to that observed in Polβ and Polλ complexed with gapped DNA substrates, prompting us to investigate if these residues play more specific roles in the precise alignment of the two ends after productive synapsis.
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