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However, when genotype-based SKAT significantly underperformed haplotype-based SKAT (e.g. Panel 1 haplotype disease scenario "Rare" and "Both models), MinP-val approach showed slightly lower power than the more powerful underlying test and greater power compared with SumP-val approach.
It is notable that both MinP-val and SumP-val achieved greater power than the more powerful underlying test for lower correlation.
Panel 2 depicts the difference in power between the combined approaches and the more powerful underlying test.
The maximum power loss of SumP-val and MInP-val compared with the more powerful underlying test across all phenotype models was 6.3% and 3.8% respectively (haplotype disease scenario "Both" model).
So, we assume that under the alternative hypothesis the non-centrality parameter (NCP) of the more powerful underlying test is, and the NCP of the less powerful underlying test is b = a/2.
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However, the complexity of multiple interacting regulators that govern these effects in cells make in vitro biochemical methods vastly more powerful to elucidate the underlying mechanisms.
Undoubtedly, a longitudinal design tracking changes in candidate biomarkers within high-risk subjects over illness development would be a much more powerful approach to understand the pathophysiology underlying illness development and to validate and refine the clinical stages.
To evaluate their joint effect on berry size, we used W-962, IND-649 and Y117 to infer a reduced set of polymorphism combinations (minihaplotypes, MH) for a haplotype-based association analysis, which has been suggested as a more powerful approach since it considers the underlying LD between different polymorphic sites [ 71, 95, 96].
This article presents the adjusted rank transform test (ART); a nonparametric test, easy to conduct, having the advantage of being much more powerful than parametric tests when certain assumptions underlying the use of these tests are violated.
Underlying those differences were two more powerful considerations, neither of which could be ignored.
By contrast, agonist-promoted dissociation of PDE from the β1AR underlies the more "diffuse" and more powerful at stimulating contraction signaling of this βAR subtype [ 6, 7].
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