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Evans et al [ 159] found a small benefit from prolonged antibiotic use to interrupt the cycle of bacterial colonisation, inflammatory change and progressive lung damage, but also advocated further, more powerful trials.
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Similarly, if ITT analysis found a suggestive although non-significant reduction in risk but a noticeably larger effect was observed in an adherent subset (as occurred in the HPTN 035 trial), then the investigators might be motivated to conduct a larger, more powerful trial.
This is further supported by the conclusion that population average models (GEE) are the more powerful test among possible methods for analyzing cluster randomized trials data [ 30].
This has an impact on power and the test is more powerful when trials are distributed uniformly across comparisons.
Our meta-analysis is more powerful (seven trials and 34 533 patients) than previously published meta-analyses in the Annals of Internal Medicine (five trials and 27 802 patients) and Lancet (five trials and 33 040 patients).
These findings suggest an interesting synergy, although more elaborate and statistically powerful trials are necessary to elucidate these findings [16].
If the trial were held in Belgrade, it would have an immediate impact on the broad citizenry that would be more powerful than if the trial were held in a foreign country.
The present study indicates further that an associative memory test with multiple learning-test trials is more powerful in amplifying the memory difference between aMCI and normal elderly.
Multiple-trial learning test tasks seemed more powerful than the tasks with single learning-test trial for MCI diagnosis [ 4- 6].
Whether gPPI or beta series methods performed more powerfully depended on experiment parameters: block designs favor the gPPI, whereas the beta series method was more powerful for designs with more trial repetitions and it also retained more power under conditions of hemodynamic response function variability.
First, we compared historical groups, whereas randomised, double-blind placebo controlled trials are more powerful.
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