The expected running time of PADE could be reduced by using more powerful mutation formula or by identifying search patterns in archive solutions, which we would investigate further in the future.
Intriguingly this deletion-promoting process appears to be quite powerful in inactivating the elements, and could be even more powerful than other mutation processes such as point mutations.
As the programs process more information in more powerful ways, the mutations are favored by a digital version of natural selection.
Nothing is more powerful than sport and, within sport, nothing is more powerful than football".
Although we studied only GBM cases, our results showed that IDH1/IDH2 mutations were more powerful prognostic factors than primary/secondary GBM classification; we observed better OS in primary GBM with mutated IDH1/IDH2 compared to the secondary GBM with no mutation).
A larger sample size is therefore required to collect sufficient mutated cases to perform a more powerful analysis of the impact of mutations on prognosis or other biological features of tumours.
A prominent example is offered by 46,XY females who have the complete form of androgen insensitivity syndrome (cAIS), when the testes produce testosterone but the body is not able to respond to androgens (testosterone and its more powerful metabolite dihydrotestosterone) due to mutation of the X-encoded androgen receptor.
The datasets of each mutation type can be combined (for example, micro-deletions, microinsertions and indels) to enable more powerful searching across comparable types of mutation.
Datasets for more than one mutation type may be combined (for example, micro-deletions, micro-insertions and indels) to enable more powerful searching across comparable types of mutation.
Whereas their methodology is capable of detecting known mutations such as the Ashkenazi mutations by designing primers flanking those mutations, our methodology is an essentially different and more powerful methodology which is designed primarily as a screening methodology.
