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There are no significant differences between the three P2Y12 inhibitors in hypothermic patients, whereas the newer inhibitors are more potent under normothermic conditions but do show slightly weaker inhibition in resuscitated patients.

Finally, we concluded that the amplitude of Ras activity becomes more potent under high expression of the ErbB4 receptor in E1/4 cells.

Indeed the effects of Pred were arguably more potent under flow than static conditions.

The inhibition of KIN-841 on 3LL cell proliferation was about five times more potent under hypoxia than under normoxia.

Sorafenib inhibits vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) signaling [ 58], thus one might hypothesize that sorafenib would be more potent under hypoxic conditions.

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What's interesting is that the car has huge brakes, wheels and tires, which would provide much more use if, say, BMW were to plunk a more potent motor under the hood.

Comparison of the cytotoxicity of KS119 in cultured cells lacking O6-alkylguanine-DNA alkyltransferase (AGT) to an agent such as Onrigin™, which through base catalyzed activation produces the same critical DNA G-C cross-link lesions by the generation of 90CE, indicates that KS119 is substantially more potent than Onrigin™ under conditions of oxygen deficiency, despite being incompletely activated.

Although 6 of 10 failing products appear more potent than the innovator under simple NLR (Table 3), in all cases it is a false impression given by their lack of bactericidal efficacy.

Novel and more potent antiplatelet agents currently under clinical development will be useful in efforts to reach these therapeutic goals.

According to data from the manufacturer, the accumulation of MitoTrackerR in active mitochondria is also dependent on the membrane potential, and since MitoTrackerR was able to stain CCCP-treated swollen mitochondria (Fig. 6C), MitoTrackerR may be a more potent probe than MitoTrackerDR under our experimental conditions.

For the past six months, stocks on Wall Street have bounced up and down apparently under nothing more potent than hope and despair.

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