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And as he returned to his office that autumn afternoon two years ago, Dr. Flaherty was already calculating the next step: he wanted to test the drug at a more potent dose before giving it to more patients in a larger trial.
One is that the former report used a more potent dose of levobupivacaine (0.25%).
With heroin, it's more common for users who inject it to overdose because it's not filtered through the liver it's going straight into the bloodstream, typically in a more potent dose than you'd be able to get from smoking.
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While a new "vaper" isn't exposed to the other substances of tar and tobacco such as are found in a normal cigarette, he or she is getting concentrated and more potent doses of nicotine.
This approach is exemplified by the antidiabetic compound troglitzone, a clinical CYP3A4 inducer which has a clinical dose of 200 600 mg and rosiglitazone a more potent analogue dose (2 12 mg) which is devoid of CYP3A4 induction in the clinic.
150 mg/kg was observed to be more potent antiemetic dose.
Oral administration of AND with 10 and 20 mg/kg significantly increases the GSH/GSSG ratio in serum, which was more potent at doses of 20 mg/kg.
Because aerosol delivery should be more potent per unit dose, our target dose for 5-Aza was 75% less than the effective systemic dose of 2 mg kg−1.
Interestingly, they had a therapeutic effect at the lowest dose tested (10 mg/kg), and that dose was more potent than the higher doses (30 and 100 mg/kg).
However, the effects of alcohol are far more potent at lower doses.
Surprisingly, low doses may even exert more potent effects than higher doses".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com