Sentence examples for more potent compounds from inspiring English sources

Crucially, these more potent compounds potently triggered lethality in HT-1080 cells via ferroptosis, as death was fully suppressed by β-ME.

Other scientists are testing additional drugs in animals to search for potentially more potent compounds.

Our analogues represent novel leads to yield more potent compounds against hemagglutinin that block viral entry.

The information obtained in the present study will be useful in designing more potent compounds.

We also discussed the SAR of these series of compounds with docking study, which may stimulate more potent compounds.

These hits are then optimized to more potent compounds via medicinal chemistry, usually facilitated by structural biology.

Whereas both the ortho- and meta-methyl were tolerated only the para-methyl 13 led to a more potent compound on both human and mouse SUCNR1.

However, by replacing the 3-pentyl with a 3-butyramido group an even more potent compound was obtained, with a Ki value of 2.8 nM, indicating that the amide function facilitates additional interactions with the binding site.

These exciting findings inspired us to design and synthesize the more potent compound 15 (IC50 0.02 μM) as a novel and highly selective inhibitor against hCE2, which was 3463-fold more potent than the parent compound GA and demonstrated excellent selectivity (>1000-fold >1000-fold.

When gingerol is dehydrated, it is converted to a more potent compound, shogaol (EC50 = 0.2 μM; 160 000 Scoville units).

TP201565 was a more potent compound in this clonogenic assay compared to APO866 and CHS-828 (10-100 fold).