Sentence examples for more potent compound from inspiring English sources

However, by replacing the 3-pentyl with a 3-butyramido group an even more potent compound was obtained, with a Ki value of 2.8 nM, indicating that the amide function facilitates additional interactions with the binding site.

These exciting findings inspired us to design and synthesize the more potent compound 15 (IC50 0.02 μM) as a novel and highly selective inhibitor against hCE2, which was 3463-fold more potent than the parent compound GA and demonstrated excellent selectivity (>1000-fold >1000-fold.

When gingerol is dehydrated, it is converted to a more potent compound, shogaol (EC50 = 0.2 μM; 160 000 Scoville units).

TP201565 was a more potent compound in this clonogenic assay compared to APO866 and CHS-828 (10-100 fold).

Thus, a switch to a more potent compound may reduce the amount of pesticide used, but would not alter its risk to the environment.

The more potent compound 3 (PDB ID: 4IQK) co-crystallized to 2.0 Å resolution where 3 binds to the Keap1 Kelch domain protein in a 1 1 stoichiometry.

Crucially, these more potent compounds potently triggered lethality in HT-1080 cells via ferroptosis, as death was fully suppressed by β-ME.

These important clues will be helpful in the design of more potent compounds in the future.

Our analogues represent novel leads to yield more potent compounds against hemagglutinin that block viral entry.

The information obtained in the present study will be useful in designing more potent compounds.

We also discussed the SAR of these series of compounds with docking study, which may stimulate more potent compounds.