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UPEI-400 was ∼1000 times more potent compared to scopoletin alone.
Particularly, 4f and 4g showed Plk1 inhibitory activity with IC50 values of 0.41 and 0.13 μM, which were about 5 and 17 times more potent compared to thymoquinone, respectively.
Compound 15b (4- benzylamino quinazolin-2-ol) was the most potent Aβ aggregation inhibitor (Aβ4- benzylamino quinazolin-2-olnd 1.4- benzylamino quinazolin-2-ol the reference agents curcumin and resveratrol.
Among this class of compounds, 2- 4-methylpiperidin-1-yl -N- naphth-1-ylmethyl pyrimidin-4-amine (9e) was identified as the most potent and selective BuChE inhibitor (IC50 = 2- 4-methylpiperidin-1-yl -N- naphth-1-ylmethyl pyrimidin-4-amineent compared to the commercial, approved reference drug galanthamine (BuChE IC50 = 12- 4-methylpiperidin-1-yl -N- naphth-1-ylmethyl pyrimidin-4-amine
In both cases, activities were more potent compared to the references antibiotics used.
LPME is more potent compared to other fractions and found in accordance with previous reports [25, 26], which have shown that high total polyphenol content increases the antioxidant activity and proves a linear correlation between phenolics content and antioxidant activity.
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In our experiments, we used WP1066, a STAT3 inhibitor that is significantly more active and potent compared to its parent compound AG490 [ 11, 13].
Desacetyl-α-MSH is considered to be unimportant for regulating energy balance despite being more potent (compared with α-MSH) at activating the appetite-regulating MC4R in vitro.
It should be noted that the inhibition was more potent compared with the inhibitory activity against EGF-induced MAPK activation.
C. copticum powder dose dependently caused reduction in eggs per gram of feces which was more potent compared with levamisole [ 67].
Inhibition with mibefradil obtained at TP30 was about seven times more potent compared with the inhibition registered at TP1; IC50 values were 4.8 and 32.7 μM, respectively.
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