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UPEI-400 was ∼1000 times more potent compared to scopoletin alone.
Desacetyl-α-MSH is considered to be unimportant for regulating energy balance despite being more potent (compared with α-MSH) at activating the appetite-regulating MC4R in vitro.
Particularly, 4f and 4g showed Plk1 inhibitory activity with IC50 values of 0.41 and 0.13 μM, which were about 5 and 17 times more potent compared to thymoquinone, respectively.
Compound 15b (4- benzylamino quinazolin-2-ol) was the most potent Aβ aggregation inhibitor (Aβ4- benzylamino quinazolin-2-olnd 1.4- benzylamino quinazolin-2-ol the reference agents curcumin and resveratrol.
Among this class of compounds, 2- 4-methylpiperidin-1-yl -N- naphth-1-ylmethyl pyrimidin-4-amine (9e) was identified as the most potent and selective BuChE inhibitor (IC50 = 2- 4-methylpiperidin-1-yl -N- naphth-1-ylmethyl pyrimidin-4-amineent compared to the commercial, approved reference drug galanthamine (BuChE IC50 = 12- 4-methylpiperidin-1-yl -N- naphth-1-ylmethyl pyrimidin-4-amine
In both cases, activities were more potent compared to the references antibiotics used.
Similar(35)
Of these, the third-generation AIs have more favorable tolerability profiles and are more selective and/or potent compared with first- and second-generation agents (Nabholtz et al, 2000; Mouridsen et al, 2001).
In our experiments, we used WP1066, a STAT3 inhibitor that is significantly more active and potent compared to its parent compound AG490 [ 11, 13].
Rodent studies suggest that kisspeptin-54 is more potent when compared with kisspepitn-10; however, their effects have not previously been directly compared in humans, or compared with direct pituitary stimulation of gonadotrophin secretion using GnRH.
A VIP analog with multiple N-terminal domains was found to be slightly more potent as compared to [Nle17]VIP towards VIP receptor type 1 (VPAC1)—related cAMP production.
Compounds with a fluorine atom at C-2 were similar or more potent antioxidants compared with the principal endogenous estrogen, 17β-estradiol.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com