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These findings will also help the design of still more potent cell penetrating analogues of maurocalcine.
DAPk is able to trans-phosphorylate ZIPk on six distinct sites in the extra-catalytic domain, thus increasing the cytoplasmic localization of ZIPk and the homo-trimerization towards a more potent cell death inducer.
We propose that PAPC functions as a molecular "governor" to limit the activity of the more potent cell adhesion inhibitor, FLRT3, and together they decrease cadherin-mediated cell adhesion in an optimal range for morphogenesis.
In contrast these malignant cells underwent a significant and more potent cell death signal when incubated with therapeutical dose of MPA (10 µg/ml) (31.1±8.3 vs 45.6±8.8).
Intriguingly, R9-rGel without the CPE targeting moiety displayed even more potent cell killing with an IC50 of 38 nM.
Selective manipulation of this process might ultimately facilitate expansion of more potent cell populations for regenerative medicine.
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Presentation via the MHC class I complex will result in a much more potent cell-mediated therapeutic immune response.
Cross-linkage of the ligand has a more potent cell-killing effect and more closely resembles the membrane-bound form of the ligand found in vivo [18].
However, we found that these compounds differently affected cell viability with CVT 11127 more potent for cell death induction than MF-438 in U2OS.
These studies highlight how even a single cell surface marker may be used in order to purify a more potent progenitor cell population for bone tissue engineering.
Pre-conditioning resulted in a more potent progenitor cell population, while aggregation induced osteochondrogenic differentiation, further enhanced by BMP-2 stimulation.
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