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Indeed, Mg and magnesium corrosion particles dose dependently reduced cytokine release from murine macrophages, with MCP being the more potent agent (Fig. 3a).
Since some activity against soft tissue sarcomas, especially leiomyosarcomas, has been reported for topoisomerase I-inhibitors, a study with a new and more potent agent seemed justified.
In that case our results suggest that ATF-BPTI is a more potent agent than endostatin or ATF.
This hypothesis is supported by the observation that switching from one VEGF-targeted therapy to another potentially more potent agent results in further responses (Rini et al, 2009).
However, its oral use has been described in non-life-threatening infections where the patients had already been stabilized with a more potent agent [ 54].
However, in this study, bupivacaine seemed to be a more potent agent than levobupivacaine in terms of desflurane use and duration of analgesia.
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If the effects produced by these substances were sufficiently potent and selective at a target site, they could be used as lead or reference compounds for the development of more potent agents.
To understand the structural basis for antifungal activity and guide in the design of more potent agents, we performed three-dimensional quantitative structure activity relationship studies for a series of compounds using comparative molecular field analysis (CoMFA).
Since hundreds of indole derivatives are commercially available and new indole derivatives are readily constructed (Bunders et al. 2011), further screening of larger libraries of indole derivatives might generate more potent agents for the eradication of human pathogens like pathogenic E. coli and S. aureus.
This information provides insights on β-tubulin residues important for maintaining microtubule structural integrity and for sensitivity to microtubule-targeting agents, and suggests novel directions for rational structure-based design of new and more potent agents for cancer treatment that target the LAU/PLA site.
These findings emphasize that more specific antiplatelet treatment regimens, which may include more potent agents or a combination with other antiplatelet drugs, are warranted in diabetic patients (20).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com