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E2F1 has more potent activator activity than E2F4 (Pierce et al. 1998b).
Full-length Aha1 is a significantly more potent activator of the ATPase activity.
Although DHT is a more potent activator of the androgen receptor (AR), T binds and activates the AR.
It is estimated that mouse liver and kidney carboxylesterase more actively hydrolyses irinotecan than either human carboxylesterase1 (hCE1) (173 vs 2.5 pmol mg−1 min−1 activity) (Xie et al, 2003) or hCE2, a more potent activator of irinotecan than human carboxylesterase1 (Humerickhouse et al, 2000).
BMP-2/6 was a more potent activator of Smad-dependent (SMAD1/5) and Smad-independent signaling (mitogen-activated protein kinases ERK and p38) than BMP-2 and BMP-6, and the activation of these pathways might play a role in its increased potency for inducing hES cell differentiation.
Our observations that caspase 8 is required for optimum NF-κB dependent gp120 mediated HIV LTR activation, and that the Casp8p43 cleavage product is a more potent activator of HIV LTR than full length caspase 8 offers insights into the biology of apoptosis.
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Downstream activation of NF-kB and the MAPK kinases by IL-33 also competitively inhibits excessive activation of these pathways by more potent activators, such as angiotensin II and phenylephrine, that are connected to increased ROS production [ 16].
Since neither the amino- nor carboxy moieties of l-His participate in interactions with amino acid moieties of the active site, they can be derivatized for obtaining more potent activators, with pharmacological applications for the enhancement of synaptic efficacy.
Apoptotic microvesicles from MRL/lpr mice are more potent activators of DC, and DC from MRL/lpr mice appear relatively more sensitive to activation by apoptotic microvesicles.
The results demonstrate that antithrombin binding and activation is a common property of these small sulfated molecules and suggests plausible directions for designing more potent activators.
Humanised antibodies are more potent activators of the human immune system than their murine equivalents.
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