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The higher expression of PODXL in the RHCC was expected, because these cancers are more poorly differentiated and PODXL expression correlates with differentiation.
The origin licensing phenotypes of normal breast and breast cancers therefore relate to their cellular differentiation status, and high-level MCM expression in more poorly differentiated tumours severely constrains their use as prognostic markers in breast cancer.
The results to date tend to support the conclusions drawn from the retrospective study for patients with the more poorly differentiated types (WHO 2 and WHO 3) of this disease.
The imaging appearance reflects the histological heterogeneity of this type of tumour, so that well-differentiated liposarcomas appear similar to fatty tissue and more poorly differentiated tumours have characteristics more similar to other sarcomatoid tumours.
We noted that there is a general trend that the number of the differentially expressed genes increases as a gastric cancer, relative to normal tissue, is more poorly differentiated, as shown in Figure 1.
More poorly differentiated gynecological cancers portended a worse prognosis, as an increased risk of death in the 10-year study period was observed in patients with moderately and poorly differentiated malignancies compared to patients with well-differentiated tumors.
Similar(13)
Cluster 3 includes patients with worse overall survival and more poorly-differentiated whereas those in cluster 1 were more well-differentiated and had a more favorable outcome.
LKB1-deficient tumors were not more advanced at the time of staging, e.g., 28% of LKB1-wild type tumors were initially Stage I (confined to the uterus), vs. 43% for LKB1-deficient tumors, nor of higher grade (i.e. more poorly-differentiated).
Men who failed to achieve a PSA decline of greater than 50% tended to have a high Gleason score (8 10) or more poorly-differentiated tumors.
Globally, these NET are more aggressive and more often poorly differentiated than NET originating from midgut [ 100].
That is, tumours with strong HLA-DR expression were significantly more often poorly differentiated (P<0.001), had more often a diploid DNA pattern (P<0.001) and were more frequent located in the right colon than in the left colon or rectum (P=0.001) (Table 1).
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