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Although observed in about 80% of sporadic colorectal tumors, the CIN phenotype is more poorly defined than MSI.
In fact, the crystallized complexes with the NAD+ molecule show a same order orientation, but without NAD, this loop region shows a more poorly defined or disordered orientation [21], [23].
However, the SI that we commonly refer to is actually more poorly defined anatomically and is known as the SI of Reichert.
Malignant teratomas contain foci of carcinoma or sarcoma; these tumors may have more poorly defined margins and more nodular soft tissue components compared to benign teratomas (Fig. 21).
Other, more poorly defined "KATP-independent" effects of glucose, possibly involving the inhibition of AMP-activated protein kinase [105,106], also contribute to "amplifying" effects of the sugar on secretion [107].
Even more poorly defined is the pathophysiology of PSH, however, some authors have proposed that that there is a release of higher inhibitory drive in the central nervous system that allows unchecked sympathetic outflow that causes the symptomatology of PSH.
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However, inflammatory or haemorrhagic bursitis may present as a more complex, poorly defined, septated collection with heterogeneous signal intensity and internal debris (Fig. 15).
In contrast, recent critiques of the use of acculturation as an explanatory variable for positive and negative changes in health behaviors in immigrant populations argue that use of language or residence time as proxies for acculturation obscures more complex and poorly defined cultural differences and their transformation over time [ 8].
However, HPA stress response during sepsis is much more complex and is poorly defined.
The clinicopathologic characteristics and prognosis of MCB, compared with other, more common histologies, are poorly defined [ 7, 8, 24, 29, 30].
As the disease progresses, the tendon thickening becomes more pronounced, there are poorly defined low echo areas within the tendon substance on US. 13 Tendon neovascularisation may be present on Doppler imaging.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com