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In presence of agonist, more platelets accumulate and increase the impedance between the wires.
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When the wall of an artery is breached, platelets accumulate there and block the flow of blood".
Platelets accumulate early, are activated at sites of tissue injury and intervene at each stage of tissue repair, the inflammatory, new tissue formation and remodelling stages.
Platelets accumulate lipids and contribute to macrophages/foam cells development and progression of vascular inflammation and atherogenesis.
Platelets accumulate and adhere to sites of vascular or tissue injury, release CXCL12, and thereby stimulate recruitment of inflammatory cells.
CD41 staining showed that platelets accumulated in Ang II-infused hearts.
Platelet aggregation is initiated post-vascular injury wherein the circulating platelets come in contact with collagen, fibronectin, vWF (von Willebrand factor) A1 domain, and the membrane glycoproteins GPIbα causing platelets to adhere to basement membrane and further initiating recruitment of more platelets to the site of injury to form a platelet plug.
This causes more platelets to arrive at the site of injury, clump together leading to platelet plug formation and is termed as primary haemostasis.
These platelets adhered both individually (upward arrows) and as strings of platelets (downward arrows) of various length, sometimes up to 20 or more platelets per string.
I wonder how many more may accumulate in my lifetime.
Eighty-five (76%) patients received one or more platelet transfusions (median 12, IQR 6-37).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com