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We next tested the effect of the inhibitory compounds in the presence of collagen, a more physiological platelet agonist than arachidonic acid.
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Although enhanced integrin αIIbβ3 activation does not lead to increased aggregation in an aggregometer tube, PKCθ−/− platelets display enhanced thrombus formation on collagen under flow, suggesting that, under more physiological conditions, the regulatory role of PKCθ may restrict thrombus size.
It's more physiological than that".
ETV is a more physiological treatment than VPS.
MR: I think the disappointment for many was that it was more physiological than action packed.
Here, we measured platelet aggregation in whole blood, i.e. in the physiological platelet environment which might differ from one group to the other.
The hallmark of this disease is severely reduced or absent platelet aggregation in response to various physiological platelet agonists such as ADP, thrombin and collagen.
But what happens under more physiological conditions?
We chose for the agonists TRAP, ADP and CRP, which stimulate the three major physiological platelet activation pathways.
However, we also found that Cl− channel blockers reduce PS exposure in response to physiological platelet activators.
84 It can also encompass a more physiological model to dynamically adapt dosing regimens at the individual level, such as proposed by Laouenan et al., who used individual predose concentrations of ribavirin and peg-IFN to predict the evolution of hemoglobin and platelet levels, respectively, in patients treated with peg-IFN/RBV and telaprevir or boceprevir.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com