Sentence examples for more physiological concentrations from inspiring English sources

Additional studies that explore the impact of more physiological concentrations on cardiac Ca2+-handling mechanisms are warranted.

Eleawa et al. [ 74] treated young intact rats with concentrations of testosterone propionate (1.5 mg/kg/week; 12 weeks) designed to produce plasma testosterone levels between 3 11 ng/ml, to mimic more physiological concentrations.

Due to the high toxicity of octyl-2-HG we switched to the less cell permeable sodium salt of 2-HG, because we aimed for more physiological concentrations in our experiments.

The present study was able to show a response even with a lower, more physiological concentration of acid.

The discrepancy to their results might be either explained by differences in the tumor cell lines or by the lower and more physiological concentration of the Hsp90 inhibitor used in our study.

Notably, our results with hRFC described herein are consistent with an earlier report in which [H]Mtx influx was up-regulated in a CCRF CEM cell line variant selected for growth in a sub-physiological level of LCV, but was substantially decreased by exposure to a higher more physiological concentration of LCV [ 24].

We then compared 50 μM DIM with a more physiological concentration of DIM (10 μM) and observed that the high concentration of the compound induces the expression of AhR target genes (CYP1A1 and CYP1B1), while the low concentration shows significant effects on the expression of ERα target genes (GREB1 and TFF1) in the absence of E2.

For lactic acid, which was used at a relatively high concentration in the RNA-seq experiment to have a similar growth inhibitory effect as the other WOAs at pH 5.5, these results were further confirmed at a more physiological concentration (64 mM) and at pH 4.5.

In particular, in the following experiments, astrocytes were exposed to a more physiological concentration of Fe2 + (5 μM), a condition that was able to promote a low, but reproducible, quenching of fura-2 (5.49% ± 1.53; ~ 30 cells per experiment from 10 separate experiments).

The impact of more physiological steroid concentrations also has been examined.

At higher more physiological salt concentrations, SSB binds in the fully wrapped binding mode and exhibits 'limited' cooperativity, where SSB forms dimers of tetramers (i.e. octamers) along the ssDNA (Bujalowski and Lohman, 1987; Lohman and Ferrari, 1994).