Sentence examples for more physiological concentration from inspiring English sources

The present study was able to show a response even with a lower, more physiological concentration of acid.

The discrepancy to their results might be either explained by differences in the tumor cell lines or by the lower and more physiological concentration of the Hsp90 inhibitor used in our study.

We then compared 50 μM DIM with a more physiological concentration of DIM (10 μM) and observed that the high concentration of the compound induces the expression of AhR target genes (CYP1A1 and CYP1B1), while the low concentration shows significant effects on the expression of ERα target genes (GREB1 and TFF1) in the absence of E2.

Notably, our results with hRFC described herein are consistent with an earlier report in which [H]Mtx influx was up-regulated in a CCRF CEM cell line variant selected for growth in a sub-physiological level of LCV, but was substantially decreased by exposure to a higher more physiological concentration of LCV [ 24].

In particular, in the following experiments, astrocytes were exposed to a more physiological concentration of Fe2 + (5 μM), a condition that was able to promote a low, but reproducible, quenching of fura-2 (5.49% ± 1.53; ~ 30 cells per experiment from 10 separate experiments).

For lactic acid, which was used at a relatively high concentration in the RNA-seq experiment to have a similar growth inhibitory effect as the other WOAs at pH 5.5, these results were further confirmed at a more physiological concentration (64 mM) and at pH 4.5.

Additional studies that explore the impact of more physiological concentrations on cardiac Ca2+-handling mechanisms are warranted.

Eleawa et al. [ 74] treated young intact rats with concentrations of testosterone propionate (1.5 mg/kg/week; 12 weeks) designed to produce plasma testosterone levels between 3 11 ng/ml, to mimic more physiological concentrations.

Due to the high toxicity of octyl-2-HG we switched to the less cell permeable sodium salt of 2-HG, because we aimed for more physiological concentrations in our experiments.

At a more physiological androgen concentration (10 nM), AR only slightly increases S-phase entry, whereas it triggers Rac 1 activation and cytoskeleton changes (migratory phenotype) in the absence of association with Src and PI3-K [4].

The impact of more physiological steroid concentrations also has been examined.