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Nodes early in the chain show responses that decay away rapidly, while those further in the chain show more persistent responses.
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Importantly, he demonstrated a rapid role for HIF-1 α, and a later and more persistent response for HIF-2 α.
These results show that delivery of FGF-1 from alginate beads stimulated a more persistent neovascularization response than bolus FGF-1 both in vitro and in vivo.
However, serological analyses have indicated that carrier animals elicit a more persistent antibody response to S. Dublin lipopolysaccharide (LPS) than recently infected animals that have eliminated the infection [ 11, 13, 16, 17].
Clinical trials conducted among approximately 10 000 persons aged 1 29 years, in India and in Africa, confirmed a vaccine safety profile similar to that of licensed polysaccharide vaccines, as well as a stronger and more persistent immunological response against group A meningococcus (MenA) [ 1, 2].
PsA-TT clinical trials that had been done in persons aged 1 29 years in India and in Africa showed that the vaccine had a safety profile similar to that of licensed meningococcal polysaccharide vaccines and produced stronger and more persistent immunological response against group A Neisseria meningitidis [ 2].
The disease in B6 mice is milder, but more chronic, with more pronounced and more persistent T-cell responses.
In established RA, the available data suggest that most patients flare upon withdrawal of a TNF inhibitor, 148 151 and more profound and persistent responses increase the likelihood of maintenance of a good outcome with csDMARDs even after withdrawal of the bDMARD.
The numbers of volunteers with positive CD8+ positive responses to AMA1 were more persistent than for CD4+ responses; after Ad-CA immunization 16/16 (100%) volunteers, at four weeks after challenge 16/17 (94%) volunteers and 12 weeks after challenge 14/15 933%) volunteers were positive.
Within the first year, the unemployment rate and the activity rate absorb about 34 and 38%%, respectively, of the labour demand shock.16 Compared to the whole sample, the response of unemployment is weaker and more persistent; in contrast, the response of the activity rate is larger and more persistent.
Stress pathway function appears to involve both rapid, posttranslational signaling for smaller, transient deviations from basal function and slower activation of transcriptional responses for more persistent, higher-level stresses (Mettetal et al. 2008).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com