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As more pathways are highlighted and additional hypotheses emerge, new projects can be born.
Our data suggest that TDP43, like other essential RNA binding proteins67, is trafficked through partially redundant and overlapping pathways, ensuring that TDP43 nuclear export will proceed unchecked even if one or more pathways are blocked.
But more pathways are sensory or nerve system related, such as chemical stimulus, neuropeptide signalling, corticospinal neuron axon decussation, Notch receptor processing, and sodium ion transport.
Also, note that our model can be easily modified to investigate scenarios where one or more pathways are not active due to the absence of expression of the pathway enzymes, by simply setting to zero the corresponding pathway rate.
Although HIF-1 is generally regulated by pVHL, it has become apparent that more pathways are involved in the regulation of basal HIF-1α levels in an oxygen- and pVHL-independent manner (reviewed in [20], [21]).
The smaller the value of, the smaller the shrinkage effect, i.e. more pathways are found to be associated.
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In stark contrast, the HFG females showed a reverse in the directionality of pathway activation, i.e. many more pathways were down-regulated uniquely compared to the male HFG animals (Figure 12).
At 24 h, more pathways were activated, especially the G-protein coupled receptor protein signaling pathway.
More pathways were found in astrocytes (Supplementary Table 14), compared to neurons (Supplementary Table 15) and OPCs (Supplementary Table 16).
With respect to the pathways altered by Rapa + DR, we also observed that more pathways were significantly changed by Rapa + DR than by either DR or Rapa alone.
We compared enriched pathways for the iMod and Greedy partitions and, even for small differences in community structures detected, more pathways were significantly enriched in the iMod partition.
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