Our analysis revealed that inclusion of the phosphoproteomic data provided more functional pathway information after integration with genomics and transcriptomics versus the integration of only genomics and transcriptomics.
Recent works also demonstrated that the detected biomarkers based on GO analysis and pathway information are more reproducible than individual marker genes [ 9].
The elucidation of degradation metabolism of A. resinae ZN1 at molecular level will facilitate the detoxification of the pretreated lignocellulose biomass and provide the metabolic pathway information for more powerful biodetoxification strain development.
Hence, in order to achieve a more convincible conclusion, further analysis using larger sample size and more complete biological knowledge base and pathway information is required, and stratified analyses on different factors such as age, sex, disease severity, and platform usage are needed.
In addition, improving coverage of human pathway information has enabled more precise diagnosis of disease states, and consequently better supervision of patient treatments, including drug therapies.
As the M. truncatula genome is currently being sequenced by an international consortium, available information on this model legume (including sequences, GO annotation, pathway information) will become more comprehensive and accurate.
As the M. truncatula genome is currently being annotated by an international consortium, available information on this model legume (including sequences, 3D structures, expression and pathway information) will become more comprehensive and accurate.
Alternatively given pathway information from Gene Ontology (GO) or KEGG for example, AMBIENCE [ 6] could spend more computation time testing SNPs within the same pathway than across pathways.
