The researchers contend that their findings may help bring future pandemics under control faster but the study also demonstrates the risk of curtailing so-called gain-of-function (GOF) studies, in which viruses are made more transmissible or more pathogenic, the researchers argue.
More than half of the hybrids were as good as their parent strains at infecting the mice, and eight of them proved to be more pathogenic, the team led by Jinhua Liu of the China Agricultural University in Beijing reports online today in the Proceedings of the National Academy of Sciences.
As shown in Figure 7, the color mutants were more pathogenic to the insect than the wild type strain Af293.
However, our findings show the first bacterial variant that is clearly more pathogenic than the existing forms of the organism, i.e., the Israeli hybrid clone, is more pathogenic than the existing biotype 1 strains within the Israeli aquaculture system.
Distinguishing Australian species is economically important, because A. luteobubalina is more pathogenic than the other members of the genus.
Careful comparison of the R. prowazekii and R. typhi genomes also demonstrated that the former species, more pathogenic than the latter, had a more decayed genome despite a 12-kb insertion that likely resulted from a single genetic event [ 59].
These subtle differences of tissue and cell tropism suggests that the mechanisms of attenuation may differ between Δ5G and SIVmac239Δnef and may further explain why the latter is likely more pathogenic than the former.
DENV types 2 and 3 native to the region may be more pathogenic than the other serotypes and thus may be recovered more frequently during human surveillance.
These results demonstrate that some reassortants between pandemic (H1N1) 2009 and seasonal influenza A (H3N2) were viable, remained transmissible, and were more pathogenic than the wild-type pandemic (H1N1) 2009 virus and emphasize the importance of monitoring reassortant viruses in surveillance programs because reassortment events may affect pathogenicity.
Two of the evaluated isolates of B. tamiae, Th239 and Th339, appear more pathogenic than the third, Th307 (Table 4).
Although the prior study clearly showed prior infection confers resistance to superinfection/viremia with a more pathogenic virus, the mechanisms of this protection remain unclear.
