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The recency control condition involved more parallel pathways, but again highlighted CA1 within the hippocampus.
As a consequence of the multiple pathways acting in concert, the cell-cycle defects increase in severity upon disruption of two or more parallel pathways.
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Fourth, in the k-OR groups there are more complex network architectures than parallel pathways e.g. branched pathways of a 4-OR architecture.
Finally, human networks are more complex and involve extensive redundant parallel pathways (Logue and Morrison, 2012), which means that new methods are required to assess the ability of proteins and combinations of proteins to affect disease progression.
Some preclinical models have suggested that combining inhibitors of both parallel pathways may be more efficacious, but it remains unknown whether dual inhibition with high enough concentrations of the drugs to achieve meaningful target inhibition is tolerable in a clinical setting.
Targeting two or more growth signaling molecules may serve to inhibit multiple parallel pathways which are collectively important for cell growth or may inhibit a single pathway more efficiently by suppressing more than one mediator along the pathway.
Interestingly, it is well recognized that more diverse microbial communities provide a wider range of parallel pathways, what in principle should ensure their overall functional stability when confronted with an environmental stress [ 6].
More recently it has been realised that proteins fold via a collection of parallel pathways which make up a funnel-shaped energy landscape (Fig. 1) [17–20].
Such complementary pathways in which a signal can be propagated through two or more parallel paths have extensively been shown to exist.
Double mutant of MUL1 with either PINK1 or parkin have a more severe phenotype than the single mutants, which suggests that MUL1 and Pink1/Parkin act in parallel pathways.
In addition, diffusion of N,N-dioctadecylaniline is found to be more rapid than expected on the basis of simple molecular volume considerations and to occur through two parallel pathways.
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