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It was shown that the lower the salt concentration, the more oxidative damage takes place in the polymer.
However increased numbers of mitochondria will also result in a further excess of ROS, which in the presence of insufficient antioxidant defense mechanisms, will produce more oxidative damage to cells.
We also found that Δ40 cells suffered ∼4 times more oxidative damage than comparable WT cells.
Consequently, it can cause more oxidative damage to mtDNA and mitochondria with further production of ROS [ 14].
Furthermore, Aβ25 35 is more rapidly toxic and causes more oxidative damage than the parent peptide Aβ1 42.
Δccc1 cells suffered more oxidative damage than WT cells, suggesting that the accumulated NHHS FeII promoted Fenton chemistry.
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It appears that Aβ25−35 could be more toxic than Aβ1−42, leading to a rapid lysis of red blood cells 97) and causing more extensive oxidative damage.
In addition, macrophages from SENCAR mice release more H2O2 and metabolites of AA, and induce more oxidative DNA damage in cocultured cells than macrophages from C57LB/6 mice.
As can be seen, cells incubated with SE-positive 15 mer peptides 65 79*0401 or 65 79*0404 prior to treatment with adenosine and then exposed to H2O2 suffered more oxidative DNA damage.
These results are in accordance with the commonly accepted assumption that extremely low frequency magnetic field enhanced the chemotherapeutic efficiency of cisplatin by increasing the production of oxygen species that caused more oxidative DNA damage.
It may be because five of the six detected H-PAHs are carcinogenic, and their higher potency may result in more oxidative stress damage than that observed in the L-PAHs, which in turn, produces a higher risk for NTDs in the exposed offspring.
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