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The University of Hull (1927) occupies a more open site in the north.
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In the wild, his cyatheas grow in the same areas as the dicksonias, but at higher altitudes and in more open sites.
By adding real identities via Facebook authentication to its social classifieds marketplace, Oodle believed it had the potential to become an appealing alternative to more open sites like Craigslist.
Pick wanted a new type of building for the more open sites of the stations on the Piccadilly line's extensions.
It is also apparent that MSM in Dar es Salaam operate in a climate of hostility from the public, with vigilante activity and murders reported, and police activity also reported (although disproportionately focused on the more open sites).
These enzymes may employ two means to promote protonation of the alkoxide intermediate: a potential proton donor or hydrogen-bonding group within the active site (His271 in PLR; Ser263 and Ser267 in PCBER), and a more open binding site that may allow access to the intermediate by bulk water.
The more open active site architecture of RgDAAO is the origin of its much broader substrate specificity.
The larger and much more open active site architectures of 2C9 may explain the weaker inhibitory affinity of chrysin towards 2C9.
Molecular dynamics simulations suggest that the mutations alter the conformational landscape of the enzyme, favoring a more open active site conformation that facilitates the reactivity of the larger substrate.
However, the increase of the substrate specificity of I86A/C295A SADH is accompanied by a decrease in the kcat/Km values of acetophenones, possibly due to the substrates fitting loosely inside the more open active site.
This could be accomplished by favoring an N/G domain organization that favors a more open active site.
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