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The lower hippocampal 5-HT turnover in F344 rats as compared to BN rats was consistent with the finding that F344 rats exhibited less anxiety (i.e., they showed more open arm exploration) than BN rats.
Post-hoc analysis of the data of the first session confirmed that the F344 rats made more open arm entries than did the Lewis and BN rats, but not the WKY rats.
In contrast, we found that the time spent in the open arms was positively correlated with the number of open arm entries - the rats that spent more time in the open arms also made more open arm entries.
Interestingly, group SC rats exhibited more open arm entries after stress exposure compared with group ST at 30 min (7.8 ± 0.9 versus 3.3 ± 0.9 times; P < 0.034) and at 60 min (7.6 ± 0.8 versus 2.9 ± 0.8 times; P = 0.006) after stress.
Isolation stress in male mice reduced anxiety as was seen by more locomotion in the open field, more open arm exploration in the EPM and more time spent in the light part of the light/dark box (Guo et al. 2004).
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Rats given ZIP prior to FS exhibited a reduction of immobility time in FS test, and more open arms (OA) entries and longer OA duration in EPM.
Though he is more open to arming the rebels than he was before reports that President Bashar al-Assad used chemical weapons, he continues to doubt that this would alter the equation on the ground.
CaMKIIα T286A mutant mice, which are deficient in autonomous and thereby overall CaMKII activity, spend more time in and entered more often the open arm in the EPM and generally react with hyperactivity to novel stimuli that could be perceived as potentially threatening (Easton et al., 2011).
The total distance covered in the EPM during the 5 min test period did not differ between WT (1634 ± 121 cm) and INI (1803 ± 143 cm) mice, nor did the percentage distance travelled on the more anxiogenic open arms of the EPM (measured in 60 s time bins) (Fig. 6B).
This contrasts to Figure 3B, where the mouse presence is more extended into the open arm and the shape is more blurred.
Interestingly Pdyn mice spent significantly more time in the open arm than the closed arm after CRF treatment (p<0.01, paired t test, closed arm vs. open arm), implying that in animals lacking dynorphin, CRF may promote exploratory behavior.
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