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The use of intensity modulated radiotherapy (IMRT) spares more normal tissue and lessens chronic side effects, but does not alleviate the acute toxicity seen in oral mucosa (Khuntia D et al., 2008) and certain patients are at a high risk of oral mucositis regardless of treatment regimen (Scully et al., 2006).
Scarring and re-epithelisation with more normal tissue tend to occur over time.
An important concern with conventional RT is dose inhomogeneity resulting in irradiation of more normal tissue.
By conforming more precisely to the selected target IMRT may allow more normal tissue to be spared than with other techniques.
Since most tumours grow with a pattern more like a sphere or spheroid, the inclusion of the extra normal tissue in the corners of the cube simply leads to irradiation of (much) more normal tissue to the full target dose.
A decreased scope of surgery was acknowledged by multidisciplinary team that one or more vital structure could be spared or more normal tissue could be preserved (PR) after neoadjuvant therapies.
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None of the genes examined were uniquely expressed in pancreatic adenocarcinomas or islet cell tumors as each was detectably expressed in one or more normal tissues.
This section will be expanded to include more normal tissues, as well as to diseased tissues.
In this technique, the prescribed dose volume was made to conform to the target volume and spare more normal tissues.
If the histopathology after surgery suggested the tumor was malignant, extensive tumor resection with more normal tissues to the tumor margin was suggested.
IMRT is a new technique that modulates the radiation beam so that it achieves a more conformal dose distribution to the target and spare more normal tissues Thus, in PCa, IMRT allows an increase of the prostate radiation dose and reduces toxicity in the rectum and bladder.
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