Sentence examples for more nonsynonymous mutations from inspiring English sources

A striking category is that 10 conjugative plasmid transfer related genes tend to accumulate more nonsynonymous mutations.

On the other hand, also for complexes III and V, Danes and southern Europeans had a similar trend with more nonsynonymous mutations in controls than in ultranonagenarians, while Finns showed no differences between ultranonagenarians and controls for both complexes.

Importantly, however, the ωe/ωi ratio of the H5N1 data sets were consistently the lowest, such that this subtype has experienced proportionally more nonsynonymous mutations on internal branches and compatible with stronger positive selection.

Although this seems to be in line with the results of the Fisher's exact test, which supported purifying selection in M. senhousia sequences, the fact that M mitochondrial genes (although less variable) showed proportionally more nonsynonymous mutations than F would contradict this (Table 1).

To further assess the likelihood of these seven recurrent genes being important to TCC development of this patient, we also scored the genes with Q-score by cancer driver prediction [ 8, 32] that believed driver genes were likely to contain significantly more nonsynonymous mutations than background mutations.

Although not all Q-score genes were higher than 1 (Additional file 10: Figure S7), we still believed all these recurrent genes were likely to be of great importance in TCC, given that the key importance of a driver gene depends on its functional impact more than just accumulation of more and more nonsynonymous mutations.

In the other two accessions, we detected more than 18,000 nonsynonymous mutations that may alter the function of ~9,000 genes.

Because ORF2 itself is not under any selection, the above phenomenon must be due to the fact that synonymous mutations to ORF2 are more likely than nonsynonymous mutations to ORF2 to be deleterious to ORF1.

We performed the same analysis also on monoallelic SNPs: due to the lack of buffering effect, selection is more effective on nonsynonymous mutations and this is reflected by the percentages of high, moderate and low effect substitutions.

Although the biological effects of nonsense mutations appear to vary widely depending on their positions and the genes, the low density of nonsense SNPs that we found suggests that nonsense mutations have more disadvantageous effects than nonsynonymous mutations.

More nonsynonymous amino-acid-changing mutations were found in the nicotinamide adenine dinucleotide dehydrogenase (NADH) complex suggesting that these changes play a role in tumor development.