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Data from our laboratory indicated that cleavage of the lecticans by the ADAMTSs loosens the ECM aggregate and promotes a more neuroplastic microenvironment.
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Human tissue (such as bone) transplanted into mice can provide a more relevant microenvironment [ 389].
Matrigel can provide a more favourable microenvironment niche for cell colonization and growth.
Expression may have been upregulated had cells been injected in a more appropriate microenvironment, e.g., via orthotopic implantation [ 40, 41].
Therefore, we aimed to study the effects of p16 in the more physiologic microenvironment of an orthotopic xenograft model.
Therefore, self-assembling peptide nanofiber hydrogel may provide a more physiological microenvironment to mediate cell-cell interaction.
Therefore, our results show that cells grown on PDMS present enhanced hepatic function by providing a more three-dimensional microenvironment.
In a more heterogeneous natural microenvironment one expects that the cell-to-cell variability in response would only increase.
Tumours are known to have a more acidic extracellular microenvironment than normal tissues.
These recipient mice clearly represent a more permissive immune microenvironment, in particular lacking natural killer cell activity.
In conclusion, IA 9464D NBL tumors have a distinct, more immunosuppressive tumor microenvironment and can be monitored using bioluminescence.
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